Inhibition of Fatty Acid Amide Hydrolase: A Potential Treatment for Neuropathic Pain
نویسندگان
چکیده
منابع مشابه
Inhibition of fatty acid amide hydrolase: a potential treatment for neuropathic pain.
(CAA)-affected vessel in the Tg2576 mouse model of amyloid deposition. Representative example of CAA in a vessel segment of a living Tg2576 mouse imaged with multiphoton microscopy. Vascular and parenchymal A deposits are identified by fluorescence from systemically administered methoxy-XO4 (red pseudocolor). Fluorescent angiograms with Texas Red dextran were performed to identify fiduciary mar...
متن کاملAnalgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain.
Cannabinoid-based medicines have therapeutic potential for the treatment of pain. Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states. The aim of this study was to determine whether local inhibition of FAAH alters nociceptive responses of spinal neurons in the spinal nerve ligation model of ...
متن کاملAnalgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic
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متن کاملRegulation of inflammatory pain by inhibition of fatty acid amide hydrolase.
Although cannabinoids are efficacious in laboratory animal models of inflammatory pain, their established cannabimimetic actions diminish enthusiasm for their therapeutic development. Conversely, fatty acid amide hydrolase (FAAH), the chief catabolic enzyme regulating the endogenous cannabinoid N-arachidonoylethanolamine (anandamide), has emerged as an attractive target for treating pain and ot...
متن کاملFatty acid amide hydrolase substrate specificity.
Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnat...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2007
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.0583-07.2007